| Mechanical activation of Beta2 Integrin Is integrin activation upon ligand binding alone or by additional mechanical stimulation necessary for intracellular cytoskeletal rearrangement? These events have implications on leukocyte arrest and migration on the endothelium as well as leukocyte extravation to tissue injury sites.
Studying integrins in leukocytes will provide an unique opportunity to define their signaling/structural properties. Understanding the influence of external stresses on cell receptors will throw light on beta2 integrin's role in cell adhesion and migration to inflammatory sites. | Projektleitung:
Prof. i. R. Dr. Wolfgang Goldmann, Ph.D.
Beteiligte:
Dipl.-Biol. Anna Klemm
Laufzeit: 1.1.2009 - 31.12.2010
Mitwirkende Institutionen:
Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, USA
Kontakt:
Goldmann, Wolfgang
Telefon +49 9131 85-25605, Fax +49 9131 85-25601, E-Mail: wolfgang.goldmann@fau.de
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