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Departments >> Faculty of Engineering >> Department of Computer Science >> Chair of Computer Science 9 (Computer Graphics) >>
SFB603 - TP C9: Reconstruction and Visualization of Neural Pathways

Neural pathways are structures within the human brain that are important for sensory, motor and other integrative functions. To avoid neurological deficits after brain surgery in brain tumor cases these fiber tracts must remain intact. Contrary to nerves of the peripheral nervous system which are coated with collateral tissue the neural pathways within the brain are hardly distinguishable from the gray matter. The differentiation of neural pathways is therefore only possible by using the capabilities of diffusion tensor MRI which measures the diffusion behavior of water molecules withing tissue. The aim of the project is to develop new approaches for the exact reconstruction of fiber tracts from diffusion tensor data which requires an exact analysis of the tensor data as well as filtering and registration techniques. In the future, the planning of surgery will be improved and the inherent risk will be reduced.
Project manager:
PD Dr.-Ing. Peter Hastreiter, Prof. Dr. med. Michael Buchfelder, Prof. Dr. med. Christopher Nimsky, Prof. Dr.-Ing. Marc Stamminger

Project participants:
Prof. Dr.-Ing. Dorit Merhof, Dr.-Ing. Frank Enders

Keywords:
Visualization; Diffusion Tensor; Neural Pathways

Duration: 1.1.2004 - 31.3.2008

Sponsored by:
Sonderforschungbereich 603

Mitwirkende Institutionen:
Neurozentrum
Neurochirurgie

Publications
Merhof, Dorit ; Hastreiter, Peter ; Soza, Grzegorz ; Stamminger, Marc ; Nimsky, Christopher: Non-linear Integration of DTI-based Fiber Tracts into Standard 3D MR Data. In: Girod, Bernd ; Magnor, Marcus ; Seidel, Hans-Peter (Ed.) : Vision, Modeling and Visualization 2004 Proceedings (Vision, Modeling and Visualization 2004 Stanford, USA 16.11.-18.11.2004). Stanford : infix, 2004, pp 371-378. - ISBN 3-89838-058-0
Merhof, Dorit ; Hastreiter, Peter ; Nimsky, Christopher ; Fahlbusch, Rudolf ; Greiner, Günther: Directional Volume Growing for the Extraction of White Matter Tracts from Diffusion Tensor Data. In: Galloway, Robert L., Jr. ; Cleary, Kevin R. (Ed.) : Visualization, Image-Guided Procedures, and Display (SPIE Medical Imaging San Diego Februar 2005). San Diego : SPIE, 2005, pp 165-172. Vol. 6, No. 21 - ISBN 0-8194-5718-3
Enders, Frank ; Merhof, Dorit ; Hastreiter, Peter ; Stamminger, Marc ; Nimsky, Christopher: Enhanced Visualization of Diffusion Tensor Data for Neurosurgery. In: Meinzer, Hans-Peter ; Handels, Heinz ; Horsch, Alexander ; Tolxdorff, Thomas (Ed.) : Bildverarbeitung für die Medizin 2005 (BVM Heidelberg 13. - 15. Maerz 2005). Heidelberg : Springer, 2005, pp .. (Informatik aktuell) - ISBN 3-540-25052-2
Enders, Frank ; Iserhardt-Bauer, Sabine ; Hastreiter, Peter ; Nimsky, Christopher ; Ertl, Thomas: Hardware-accelerated Glyph Based Visualization of Major White Matter Tracts for Analysis of Brain Tumors. In: Galloway, Robert L., Jr. ; Cleary, Kevin R. (Ed.) : Visualization, Image-Guided Procedures, and Display (SPIE Medical Imaging San Diego Februar 2005). San Diego : SPIE, 2005, pp 504-511. Vol. 6, No. 21 - ISBN 0-8194-5718-3
Merhof, Dorit ; Enders, Frank ; Vega Higuera, Fernando ; Hastreiter, Peter ; Nimsky, Christopher ; Stamminger, Marc: Integrated Visualization of Diffusion Tensor Fiber Tracts and Anatomical Data. In: Schulze, Thomas ; Horton, Graham ; Preim, Bernhard ; Schlechtweg, Stefan (Ed.) : Simulation und Visualisierung 2005 (Simulation und Visualisierung 2005 Magdeburg 3.-4. Maerz 2005). Erlangen : SCS Publishing House e.V., 2005, pp 153-164. - ISBN 3-936150-40-0
Nimsky, Christopher ; Ganslandt, Oliver ; Hastreiter, Peter ; Wang, Ruopeng ; Brenner, Thomas ; Sorensen, Gregory ; Fahlbusch, Rudolf: Intraoperative diffusion-tensor MR imaging: shifting of white matter tracts during neurosurgical procedures - initial experience. In: Radiology 234 (2005), No. 1, pp 218-25
Nimsky, Christopher ; Ganslandt, Oliver ; Hastreiter, Peter ; Wang, Ruopeng ; Brenner, Thomas ; Sorensen, Gregory ; Fahlbusch, Rudolf: Preoperative and intraoperative diffusion tensor imaging-based fiber tracking in glioma surgery. In: Neurosurgery 56 (2005), No. 1, pp 130-7
Merhof, Dorit ; Sonntag, Markus ; Enders, Frank ; Hastreiter, Peter ; Fahlbusch, Rudolf ; Nimsky, Christopher ; Greiner, Günther: Visualization of Diffusion Tensor Data using Evenly Spaced Streamlines. In: Greiner, Günther ; Hornegger, Joachim ; Niemann, Heinrich ; Stamminger, Marc (Ed.) : Vision, Modeling and Visualization 2005 Proceedings (Vision, Modeling and Visualization 2005 Erlangen 16.11.-18.11.2005). Erlangen : infix, Aka GmbH, 2005, pp 257-264. - ISBN 3-89838-068-8
Nimsky, Christopher ; Ganslandt, Oliver ; Enders, Frank ; Merhof, Dorit ; Fahlbusch, Rudolf: Visualization strategies for major white matter tracts identified by diffusion tensor imaging for intraoperative use. In: Lemke, Heinz ; Inamura, Kiyonari ; Doi, Kunio ; Vannier, Michael ; Farman, Allan (Ed.) : Computer Assisted Radiology and Surgery (Computer Assisted Radiology and Surgery Berlin 22.-25.06.2005). Berlin : Elsevier, 2005, pp 793-797. (International Congress Series Vol. 1281) - ISBN 0-444-51872-X
Enders, Frank ; Sauber, Natascha ; Merhof, Dorit ; Hastreiter, Peter ; Nimsky, Christopher ; Stamminger, Marc: Visualization of White Matter Tracts with Wrapped Streamlines. In: IEEE (Org.) : Proc. IEEE Visualization 2005 (IEEE Visualization 2005 Minneapolis 23.-28.10.05). 2005, pp 51-58.
Merhof, Dorit ; Richter, Mirco ; Enders, Frank ; Hastreiter, Peter ; Ganslandt, Oliver ; Buchfelder, Michael ; Nimsky, Christopher ; Greiner, Günther: Fast and Accurate Connectivity Analysis between Functional Regions based on DT-MRI. In: Medical Image Computing and Computer-Assisted Intervention (MICCAI) (Org.) : Medical Image Computing and Computer-Assisted Intervention (MICCAI) (Medical Image Computing and Computer-Assisted Intervention (MICCAI) Kopenhagen, Dänemark 01.-06.10.2006). Vol. 4191. Heidelberg : Springer, 2006, pp 225-233.
Merhof, Dorit ; Enders, Frank ; Hastreiter, Peter ; Ganslandt, Oliver ; Fahlbusch, Rudolf ; Nimsky, Christopher ; Stamminger, Marc: Neuronal Fiber Connections based on A-Pathfinding. In: Manduca, Armando ; Amini, Amir A. (Ed.) : Physiology, Function, and Structure from Medical Images (SPIE Medical Imaging San Diego, CA, USA 11.-16.02.2006). Vol. 6143. 2006, pp 1S, 1-8.
Merhof, Dorit ; Sonntag, Markus ; Enders, Frank ; Nimsky, Christopher ; Hastreiter, Peter ; Greiner, Günther: Hybrid Visualization for White Matter Tracts using Triangle Strips and Point Sprites. In: IEEE Transactions on Visualization and Computer Graphics 12 (2006), No. 5, pp 1181-1188
Nimsky, Christopher ; Ganslandt, Oliver ; Merhof, Dorit ; Sorensen, A. Gregory ; Fahlbusch, Rudolf: Intraoperative visualization of the pyramidal tract by DTI-based fiber tracking. In: Neuroimage 30 (2006), No. 4, pp 1219-1229
Merhof, Dorit ; Soza, Grzegorz ; Stadlbauer, Andreas ; Greiner, Günther ; Nimsky, Christopher: Correction of susceptibility artifacts in diffusion tensor data using non-linear registration. In: Medical Image Analysis 11 (2007), No. 6, pp 588-603
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