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Schwerpunktfach Biomaterials and Bioprocessing (Bio focal)15.0 ECTS (englische Bezeichnung: Focal subject Biomaterials and Bioprocessing)
Modulverantwortliche/r: Aldo R. Boccaccini Lehrende:
Aldo R. Boccaccini, Sannakaisa Virtanen, Ruth Freitag, Rainer Detsch, Joachim Kaschta, Stephan E. Wolf
Studienfächer/Prüfungsordnungsmodule:
Einfrieren der UnivIS-Modul-Beschreibung: 29.3.2021
Schwerpunkt Biomaterials and Bioprocessing (114760)
Startsemester: |
SS 2021 | Dauer: |
2 Semester | Turnus: |
halbjährlich (WS+SS) |
Präsenzzeit: |
120 Std. | Eigenstudium: |
330 Std. | Sprache: |
Englisch |
Lehrveranstaltungen:
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Immobilisation of cells and characterisation of membranes (SS 2021)
(Vorlesung, 2 SWS, Ruth Freitag, Di, 16:15 - 17:45; via Zoom, details available on StudOn. Registration is mandatory!)
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Biomaterials for Tissue Engineering (SS 2021)
(Vorlesung, 2 SWS, Aldo R. Boccaccini et al., Di, 12:15 - 13:45, Zoom-Meeting; ab 20.4.2021)
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Biomimetic synthesis of materials (WS 2021/2022)
(Vorlesung, 2 SWS, Stephan E. Wolf, Mi, 16:15 - 17:45, 0.15; ab 27.10.2021)
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Application of Cell Technology (WS 2021/2022)
(Vorlesung, 2 SWS, Rainer Detsch et al., Mi, 14:15 - 15:45, SemR-USS)
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Polymerwerkstoffe in der Medizin (WS 2021/2022)
(Vorlesung, 2 SWS, Joachim Kaschta, Mo, 14:15 - 15:45, 1.84; ab 25.10.2021)
Inhalt:
- Immobilisation system
High density cell culture bioreactors
Microcarriers - advantages and disadvantages
Surface binding (adhesion)
Matrix properties
DLVO Theory
Modified surfaces
Flocculation and Coagulation
Van der Waals Forces and electrostatic forces
Principle of polymer flocculation
Flocculation with yeast cells
Flocculation breakage
Floc strength
Breakage models
Antibody binding
ELISA
Tumor therapy
Magnetic associated cell sorting (MACS)
Entrapment methods
Hollow fiber reactor
Encapsulation
Encapsulation technology
Droplet formation
Membrane characterization
Categories of membranes for Life Science application
Membrane materials
Membrane based processes
Applications in the biopharmaceutical industry and in medicine/medtech
Biomimetic Synthesis of Materials (Prof. Wolf):
The course "Biomimetic Materials and Processing" introduces the fundamental principles of design and processing which give rise to the key features exhibited by biological materials. Processes and concepts of growth, form, and development are discussed, with a special focus on evolutionary optimization strategies. Basic biochemical and microbiological aspects in respect to self-assembly, stimuli-response and adaptation of functional biomaterials are covered. Fundamental processes of biomineralization is discussed along with the key properties and functions which biominerals exhibit. The translation of these concepts to bio-inspired materials and processes for manufacturing biomimetic functional materials are presented along with the challenges and limits of such a biomimetic approach. The course is completed leading through smart materials and application prospects of biomimetic materials. Application of cell technology (Dr. Detsch):
This course introduces the basics of biochemistry, cells and cell culture technique. Based on this knowledge, the students will learn how cells interact with biomaterials and how material parameters are influencing protein adsorption, cell adhesion, proliferation and differentiation. Also techniques to study these interactions are discussed in this course. With regards to biomedical engineering, characteristics of cell lines, primary and stem cells are further focal points. To understand the different approaches of tissue engineering, materials, growth factors and bioreactors will be discussed. Based on different hard and soft tissue examples, angiogenesis and tissue regeneration will be focused. Moreover, concepts of biofabrication will be introduced.
Lernziele und Kompetenzen:
Cells, Membranes and Tissue Engineering:
The students achieve extensive knowledge in the field of cell cultivation including cell immobilization, cell interaction and membrane interactions. Furthermore, the students analyze typical situations of application of membrane technology in the life sciences and to propose possible solutions based on understanding of both process and material aspects. Biomimetic Materials:
The students
elaborate differences between bionic and biomimetic sciences
discuss the limits of biomimetic approaches
identify and elaborate on the basic design principles in biological materials
give an account on the structure, processing, and function of various classic examples of biological functional materials with a special regard to biological ceramic materials, i.e. biominerals
adapt design concepts used in natural systems to synthesis for the development of new functional materials.
Application of Cell Technology:
This course introduces the basics of biochemistry, cells and cell culture technique. Based on this knowledge, the students will learn how cells interact with biomaterials and how material parameters are influencing protein adsorption, cell adhesion, proliferation and differentiation. Also techniques to study these interactions are discussed in this course. With regards to biomedical engineering, characteristics of cell lines, primary and stem cells are further focal points. To understand the different approaches of tissue engineering, materials, growth factors and bioreactors will be discussed. Based on different hard and soft tissue examples, angiogenesis and tissue regeneration will be focused. Furthermore, students will learn basics about additive manufacturing, hydrogels and cellprinting. This leads to the field of biofabrication. Polymers in Medical Application:
The students understand which factors from the polymer structure (chemical as well as molecular), determine the use of certain polymers in a selected medical application. The students can apply their knowledge to choose a polymer for a given medical application. Additionally, ways of modifying polymers for certain applications are discussed (e.g. reinforcement, surface modification) together with its theoretical background. The students can analyse structure property relationships being relevant for medical applications of polymers.
Literatur:
Biomimetic Materials:
E Bäuerlein, Biomineralization, Wiley-VCH (2004)
TX Fan, SK Chow, D Zhang, Biomorphic mineralization: From biology to materials, Progress in Materials Science 54 (2009) 542 - 659
P Gomez-Romero, C Sanchez Functional Hybrid Materials, Wiley-VCH (2004)
Application of Cell Technology:
Di Silvio (ed.): Cellular Response to Biomaterials; Cambridge u.a., 2009
KC Dee, DA Puleo and R Bizios: Tissue-Biomaterial-Interaction; Wiley-Liss New Jersey, ISBN 0-471-25394-4
B. D. Ratner et al. (eds.): Biomaterials Science, 2nd Ed., Elsevier, 2004.
Detsch R, Will J, Hum J, Roether JA, Boccaccini AR. Biomaterials. In 2018. p. 91–105. Available from: http://link.springer.com/10.1007/978-3-319-74854-2_6
Ovsianikov, Aleksandr, Yoo, James, Mironov, Vladimir (Eds.)3D Printing and Biofabrication, ISBN 978-3-319-45445-0
Polymers in Medical Applications:
Wintermantel E.; Ha, S.W.; Medizintechnik - Life Science Engineering, Springer, 5th. ed. 2009
Mahapatro A. (ed.); Polymers for biomedical applications 2nd ed. Oxford, 2005
Weitere Informationen:
Schlüsselwörter: Elitestudiengang "Advanced Materials and Processes"
www: https://www.map.tf.fau.de/
Studien-/Prüfungsleistungen:
Biomaterials and Bioprocessing 1: Cells, Membranes and Tissue Engineering (Prüfungsnummer: 1806)
(englischer Titel: Biomaterials and Bioprocessing 1: Cells, Membranes and Tissue Engineering)
zugeh. "mein campus"-Prüfung: | - 1806 Biomaterials and Bioprocessing 1: Cells, Membranes and Tissue Engineering (Gewichtung: 50.0 %, Advanced Materials and Processes (Master of Science) 2019w, Prüfung, Form: schriftlich oder mündlich, Drittelnoten (mit 4,3), Dauer: -, 7.5 ECTS, Prüfung).
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- Prüfungsleistung, mündliche Prüfung, Dauer (in Minuten): 45, benotet, 7.5 ECTS
- Anteil an der Berechnung der Modulnote: 50.0 %
- Prüfungssprache: Englisch
- Erstablegung: SS 2021, 1. Wdh.: WS 2021/2022
1. Prüfer: | Aldo R. Boccaccini (100550) |
Biomaterials and Bioprocessing 2: Applied Biomaterials Synthesis and Cell-Materials Interactions (Prüfungsnummer: 1807)
(englischer Titel: Biomaterials and Bioprocessing 2: Applied Biomaterials Synthesis and Cell-Materials Interactions)
zugeh. "mein campus"-Prüfung: | - 1807 Biomaterials and Bioprocessing 2: Applied Biomaterials Synthesis and Cell-Materials Interactions (Gewichtung: 50.0 %, Advanced Materials and Processes (Master of Science) 2019w, Prüfung, Form: schriftlich oder mündlich, Drittelnoten (mit 4,3), Dauer: -, 7.5 ECTS, Prüfung).
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- Prüfungsleistung, mündliche Prüfung, Dauer (in Minuten): 45, benotet, 7.5 ECTS
- Anteil an der Berechnung der Modulnote: 50.0 %
- Prüfungssprache: Englisch
- Erstablegung: WS 2021/2022, 1. Wdh.: SS 2022
1. Prüfer: | Aldo R. Boccaccini (100550) |
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