Molecular synthesis (MSM-ME1)15 ECTS (englische Bezeichnung: Molecular synthesis)
(Prüfungsordnungsmodul: Wahlpflichtmodul Molecular Science)
Modulverantwortliche/r: Andreas Hirsch Lehrende:
Andreas Hirsch, Karsten Meyer, Svetlana Tsogoeva, Ivana Ivanovic-Burmazovic, Nicolai Burzlaff, Julien Bachmann, Frank Wilhelm Heinemann, Marcus Speck, Andreas Scheurer
Start semester: |
SS 2019 | Duration: |
2 semester | Cycle: |
halbjährlich (WS+SS) |
Präsenzzeit: |
210 Std. | Eigenstudium: |
240 Std. | Language: |
Englisch |
Lectures:
Check for other alternatives in UnivIS
NB: no overlap with courses in Mandatory Module allowed
- A. LAB course Molecular Synthesis
either in Inorganic or Organic Chemistry (6LAB/1S)
(Attendance in lab course is compulsory!)
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Lab course Molecular Synthesis - IC (SS 2019)
(Praktikum, Die Dozenten der Anorg. Chemie et al., Praktikumsanmeldung per E-Mail bei Dr. Achim Zahl 4-6 Wochen vor dem gewünschten Praktikumsbeginn)
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Praktikum Organische Molekülsynthesen - Masterstudium / Lab Course Molecular Synthesis OC - Master-level program (WS 2019/2020)
(Praktikum, 7 SWS, Svetlana Tsogoeva et al., Chemikum: 27.01. - 06.03.2020; further information in the introduction and safety instruction session (attendance compulsory!))
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Praktikum Anorganische Molekülsynthesen - Masterstudium / Lab Course Molecular Synthesis IC - Master-level program (WS 2019/2020)
(Praktikum, Karsten Meyer et al., registration and contact: Dr. A. Zahl)
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Challenges in Organic Chemistry / Seminar: Syntheseprobleme in der Organischen Chemie (SS 2019)
(Hauptseminar, 2 SWS, Andreas Hirsch et al., Wed, 16:00 - 17:30, C3 - Chemikum)
- Lectures & Seminars:
- B. Advanced Inorganic Chemistry I (2L/1S)
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Advanced Inorganic Chemistry (WS 2019/2020)
(Vorlesung, 2 SWS, Ivana Ivanovic-Burmazovic et al., Wed, 13:15 - 14:45, H3 Egerlandstr.3)
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Advanced Inorganic Chemistry - Seminar (WS 2019/2020)
(Seminar, 1 SWS, Ivana Ivanovic-Burmazovic et al., Fri, 13:15 - 14:00, H2 Egerlandstr.3)
-
Advanced Inorganic Chemistry - Seminar Talk (Vortragsseminar zum Fortgeschrittenenpraktikum Anorganische Chemie ) (WS 2019/2020)
(Seminar, 1 SWS, Andreas Scheurer)
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Advanced Inorganic Chemistry - Practical / Fortgeschrittenenpraktikum Anorganische Chemie (WS 2019/2020)
(Praktikum, 8 SWS, Karsten Meyer et al., contact: Dr. A. Zahl)
- C. Advanced Inorganic Chemistry II (1L)
choice of 1 course from
C1: Bioinorganic chemistry I (1L)
C2: Metals in medicine (1L)
C3: Nanoparticles and nanostructured thin films (1L)
C4: Modern X-Ray structure determination of single crystals (2L)
-
Bioinorganic Chemistry I, Metalloenzymes and Metals in Medicine (WS 2019/2020)
(Vorlesung, 2 SWS, Nicolai Burzlaff, Tue, 10:15 - 11:45, A00.14)
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Metalle in der Medizin für Molekularwissenschaftler / Metalloenzymes and Metals in Medicine (WS 2019/2020)
(Vorlesung, 1 SWS, Nicolai Burzlaff, Wed, 12:15 - 13:00, A00.14)
-
Nanoparticles and Nanostructured Thin Films / Nanopartikel und nanostrukturierte dünne Schichten (WS 2019/2020)
(Vorlesung, 2 SWS, Julien Bachmann, Mon, 12:15 - 14:00, H2 Egerlandstr.3; Institut für Anorganische Chemie, Egerlandstraße 1; starts 2nd week of the term; Seminar: time and place by agreement!)
-
Modern X-ray structure determination of single crystals/Einführung i. d. Kristallstrukturbestimmung von Molekülverbindungen (SS 2019)
(Vorlesung mit Übung, 2 SWS, Frank Wilhelm Heinemann et al., time and place by agreement; please contact Dr. Heinemann (frank.heinemann@fau.de) latest till Friday in the first week of lectures!)
- D. Advanced Organic Chemistry I (2L)
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Advanced Organic Chemistry I - Synthesis and Catalysis/Fortgeschrittene Organische Chemie I - Synthese und Katalyse (WS 2019/2020)
(Vorlesung, 2 SWS, Svetlana Tsogoeva et al., Fri, 10:15 - 11:45, C3 - Chemikum)
- E. Advanced Organic Chemistry II (2L)
choice of 1 course from
E1: Organocatalysis (2L)
E2: Chemie der Naturstoffe (2L)
E3: Radical Chemistry (2L)
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Organocatalysis and catalytic reactions in water (SS 2019)
(Vorlesung, 2 SWS, Svetlana Tsogoeva et al., Fri, 12:30 - 14:00, C3 - Chemikum)
-
Seminar: Chemie der Naturstoffe (SS 2019)
(Hauptseminar, 2 SWS, Marcus Speck et al., Tue, 10:00 - 12:00, 00.111 - Chemikum)
-
Current issues in Organic Chemistry I/II (Advanced Organic Chemistry II) (SS 2019)
(Seminar, 2 SWS, Andreas Hirsch et al., Tue, 14:00 - 17:00, C3 - Chemikum; Wed, 8:15 - 9:45, C3 - Chemikum; starting 30.4.2019; Attendance is compulsory at the first lecture! Follow-up appointments will be announced.)
Inhalt:
A: Advanced chemical synthesis and molecular analysis B: Inorganic and coordination chemistry principles; application of spectroscopic methods; advanced reaction mechanisms and experimental methods; important catalytic processes driven by metal complexes; design and synthesis of catalysts, physiologically active substances and new materials based on transition metals compounds D:
Modern synthetic methods in organic chemistry: pericyclic reactions,
heterocycle syntheses, modern catalytic methodologies (metal-, organo- and biocatalysis), strategies in stereoselective synthesis C1:
Metal binding to proteins and DNA; functions of metal ions in enzymes; O2transport, storage and activation; electron transfer in proteins; heme and non-heme iron containing oxygenases; zinc peptidases and proteases; superoxide dismutases; copper containing enzymes; biological function of nickel, molybdenum and tungsten; concepts and synthesis of model complexes; basics of Photosynthesis C2:
Platinum based anticancer drugs; Ruthenium and gold based metallotherapeutics; silapharmaca; Li therapeutics; boron neutron capture therapy; MnSOD; insulin mimetic vanadium containing compounds; magnetic resonance imaging (MRI); cobalamin; metal poisoning; Hg in the biosphere; metallotherapeutic arsenic compounds; technetium radiodiagnostics; antimony in medicine; bismuth based pharmaceuticals C3:
Synthesis of n-dimensional nano-materials. Systematic approaches
towards nano-particles of defined size and structure are the basis to prepare materials with taylor-made electronic, optical or catalytic properties. The interplay between nano-particles, nano-rods, nano-wires, 2- and 3-dimentional materials are highlighted. C4:
Fundamentals of crystallization; polymorphism; structural description of crystals, crystal systems, unit cell, symmetry and symmetry elements, space groups; diffraction power of crystals, diffraction conditions, structure factor; generation of X-rays, single crystal diffractometers, data collection, data reduction; structure solution and refinement, problems and pitfalls, anomalous dispersion and absolute structure, interpretation of results, graphical representations, data bases. E1:
General concepts of organocatalysis. Enamine/iminiumion activation by Lewis basic amines. Noncovalent catalysis with ureas, thioureas and diols. Brønsted- and Lewis-acid catalysis. Phase-transfer catalysis. Bi- and multi-functional catalysts. Iminium/Enamine cascade catalysis. Organocatalytic domino reactions; natural product and chiral drug synthesis. E2:
Structure, isolation and structure elucidation of natural products;
biosynthesis and degradation of carbon hydrates, lipids, peptides and
terpenoids; biological and medicinal aspects of tetrapyrrols and
alkaloids; technical synthesis of vitamins E3:
Radical reactivity; time scales and radical clock experiments; electrophilic and nucleophilic radicals; radical initiators; radical generation by oxidation or reduction; tin hydrides and modern replacements; atom and group transfer reactions; generation of various carbon-centered radicals; generation of oxygen- and nitrogencentered radicals.
Lernziele und Kompetenzen:
The students are able
to understand and to explain the principles of advanced chemical synthesis routes and molecular analysis in organic and inorganic chemistry
to understand the functionality of various molecular systems
to participate in planning, developing and executing of experimental routes for the synthesis of more complex molecular systems
to characterize molecular samples (natural compounds, e.g., peptides or vitamins, or metal-based drugs) using modern experimental methods and techniques
to interpret and critically summarize experimental results in written form (lab report in paper-style format)
to work in smaller research teams (team ability).
Organisatorisches:
Intended stage in the degree course: Mandatory elective module (Wahlpflichtmodul) or Elective module (Wahlmodul), semester 1-3
Frequency of offer: start of studies is available in summer and winter term
A: upon appointment with contact persons
B & D: winter term
E1/E2: summer term; E2 also winter term;
E3: winter term
C1/C2/C3: winter term
Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan:
- Molecular Science (Master of Science)
(Po-Vers. 2013 | NatFak | Molecular Science (Master of Science) | Wahlpflichtmodul Molecular Science)
Studien-/Prüfungsleistungen:
Molekülsynthesen - Molecular Synthesis (Prüfungsnummer: 30801)
(englischer Titel: Molecular Synthesis)
zugeh. "mein campus"-Prüfung: | - 30801 Molekülsynthesen - Molecular Synthesis (Prüfung, Form: mündliche Prüfung, Drittelnoten (mit 4,3), Dauer: 45, 15.0 ECTS, Prüfung).
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- Prüfungsleistung, mündliche Prüfung, Dauer (in Minuten): 45, benotet
- Anteil an der Berechnung der Modulnote: 100.0 %
- weitere Erläuterungen:
Assessment and examinations:
O45 (PL) + LAB (SL): oral examination (45 min), 2 Examiners +
Lab course protocol(s), ungradedCalculation of the grade for the module: 100% from oral examination
- Prüfungssprache: Englisch
- Erstablegung: WS 2019/2020, 1. Wdh.: SS 2020
1. Prüfer: | Karsten Meyer (070542) |
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