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ILS-MA-I4: Spatial Modeling of Metabolic Processes (ILS-MA-I4)10 ECTS (englische Bezeichnung: ILS-MA-I4: Räumliche Modelle von Stoffwechselprozessen)
(Prüfungsordnungsmodul: Spatial Modeling of Metabolic Processes)
Modulverantwortliche/r: Uwe Sonnewald, Maria Neuss-Radu Lehrende:
Uwe Sonnewald, Maria Neuss-Radu, Wolfgang Zierer
weitere Studienfächer/Prüfungsordnungsmodule:
Räumliche Modelle der Stoffwechselregulation (41120)
Spatial Modeling of Metabolic Processes (85170)
Start semester: |
WS 2020/2021 | Duration: |
1 semester | Cycle: |
jährlich (WS) |
Präsenzzeit: |
120 Std. | Eigenstudium: |
180 Std. | Language: |
Englisch |
Lectures:
Empfohlene Voraussetzungen:
Suggested: Module Partial differential equations for life sciences
Inhalt:
Lecture
a) The biological part deals with the following topics:
Metabolic Networks
Allosteric Regulation of Metabolism – The dual role of metabolites as signalling molecules and intermediates
Metabolite Channeling
Reversible Formation of Protein Complexes
Concepts of Synthetic Biology
Membrane Transport and Membrane Association of Proteins
b) Within the mathematical part, the mathematical modeling of the processes studied in the biological part is performed and the models are simulated by using standard simulation software like e.g. Matlab. The mathematical and simulation approaches include:
modelling approaches accounting for the spatial structure of cells: compartments, organelles, membrane systems and the spatial distribution of enzymes and metabolites
a hierarchy of mathematical models are considered, including compartment models (systems of coupled ordinary differential equations) and continuous models in space and time (systems of partial differential equations) like reaction -diffusion-transport systems subjected to appropriate boundary and transmission conditions
implementation of temporal and spatial discretizations for transmission problems in Matlab or other simulation software.
Laboratory course
Metabolite quantitation by HPLC-tandem mass spectrometry. Protein biochemistry to assess the architecture of protein complexes: differential centrifugation, SDS-PAGE, western blot, etc.
Tutorial
Within the tutorial, the mathematical notions are discussed and deepened by means of blackboard and computer homework
Lernziele und Kompetenzen:
Students
gain insight into feedback regulation of plant metabolism by metabolic intermediates
learn to conduct advanced analytical methods
are in touch with state-of-the art research topics
will be trained to apply the acquired knowledge on the analysis of protein complexes
acquire a in-depth knowledge and understanding in the area of mathematical modelling of intracellular processes
compare different modelling and simulation approaches and interpret the results in the framework of the biological application
investigate working methods from different disciplines (biology and mathematics) and develop new interdisciplinary approaches.
Literatur:
A course in Mathematical Biology,de Vries, Hillen, Lewis, Müller, Schönfisch, 2006
Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan:
- Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science)
(Po-Vers. 2019w | NatFak | Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science) | Module Groups | MG1: Mathematical Modelling and Systems Biology | Mandatory Elective Modules Group 1 | Spatial Modeling of Metabolic Processes)
Dieses Modul ist daneben auch in den Studienfächern "643#65#H" verwendbar. Details
Studien-/Prüfungsleistungen:
Spatial Modeling of Metobolic Processes (Prüfungsnummer: 81421)
zugeh. "mein campus"-Prüfung: | - 81421 Spatial Modeling of Metobolic Processes (Gewichtung: 100.0 %, Prüfung, Form: schriftlich oder mündlich, Drittelnoten (mit 4,3), Dauer: 60, 10 ECTS, Prüfung).
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- Prüfungsleistung, Klausur, Dauer (in Minuten): 60, benotet, 10 ECTS
- Anteil an der Berechnung der Modulnote: 100.0 %
- Erstablegung: WS 2020/2021, 1. Wdh.: SS 2021
1. Prüfer: | Maria Neuss-Radu (060176) |
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