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Retrospective Motion Compensation in Optical Coherence Tomography

Optical coherence tomography (OCT) opens up the possibility to perform non-invasive, in vivo, micron scale 2D and 3D imaging of scattering tissue, such as the retina. Using 3D-OCT, quantitative measurements can be performed in ophthalmology, facilitating early detection and treatment of eye diseases, such as glaucoma and diabetic retinopathy. 3D-OCT datasets are not acquired instantaneously but are composed of many 1D axial scans recorded within few seconds. Thus, datasets show distortions and artefacts that result from motion of the eye during the scan. OCT images also contain speckle noise. We approach these problems by using multiple 3D scans of an area which are registered with each other to correct for motion and are combined so that speckle noise is reduced. OCT images with different scanning patterns are used to retrospectively estimate and compensate object motion. A novel software only registration method based on the optimization of a global, problem-specific objective function that is able to correct motion in all three dimensions is proposed. It offers great potential for achieving both more accurate data and improved image quality without the additional cost and complexity of hardware based motion correction methods. The ability to accurately and repeatably image the retina could improve the early, accurate diagnosis of disease and monitoring of treatment.
Project manager:
Prof. Dr.-Ing. Joachim Hornegger, Prof. Dr. Christian Y. Mardin, Prof. Dr. med. Friedrich E. Kruse

Project participants:
Dr.-Ing. Martin Kraus

Keywords:
Optische Kohaerenztomographie; Bildregistrierung; Bewegungskorrektur; Signalverbesserung; Medizinische Bilddaten

Duration: 1.7.2013 - 30.6.2014

Sponsored by:
Deutsche Forschungsgemeinschaft

Mitwirkende Institutionen:
Augenklinik Erlangen
Massachussets Institute of Technology

Contact:
Kraus, Martin
Publications
Liu, Jonathan J. ; Grulskowski, Ireneusz ; Potsaid, Benjamin M. ; Jayaraman, Vijaysekhar ; Cable, Alex E. ; Kraus, Martin ; Hornegger, Joachim ; Duker, Jay S. ; Fujimoto, James G.: 4D dynamic imaging of the eye using ultrahigh speed SS-OCT. In: SPIE (Ed.) : Proc. SPIE 8567 (Ophthalmic Technologies XXIII San Francisco 02.02.2013). 2013, pp 85670X.
[doi>10.1117/12.2004369]
Kajic, Vedran ; Esmaeelpour, Marieh ; Glittenberg, Carl ; Kraus, Martin ; Hornegger, Joachim ; Othara, Richu ; Binder, Susanne ; Fujimoto, James G. ; Drexler, Wolfgang: Automated three-dimensional choroidal vessel segmentation of 3D 1060 nm OCT retinal data. In: Biomedical Optics Express 4 (2013), No. 1, pp 134-150
[doi>10.1364/BOE.4.000134]
Köhler, Thomas ; Budai, Attila ; Kraus, Martin ; Odstrcilik, Jan ; Michelson, Georg ; Hornegger, Joachim: Automatic No-Reference Quality Assessment for Retinal Fundus Images Using Vessel Segmentation. In: IEEE (Ed.) : 2013 26th IEEE International Symposium on Computer-Based Medical Systems (CBMS) (International Symposium on Computer-Based Medical Systems Porto, Portugal 2013). 2013, pp 95-100.
[doi>10.1109/CBMS.2013.6627771]
Liu, Jonathan J. ; Grulskowski, Ireneusz ; Kraus, Martin ; Potsaid, Benjamin ; Lu, Chen D. ; Baumann, Bernhard ; Duker, Jay S. ; Hornegger, Joachim ; Fujimoto, James G.: In vivo imaging of the rodent eye with swept source/Fourier domain OCT. In: Biomedical Optics Express 4 (2013), No. 2, pp 351-363
[doi>10.1364/BOE.4.000351]
Ahsen, Osman O. ; Tao, Yuankai K. ; Potsaid, Benjamin M. ; Sheikine, Yuri ; Jian, James ; Grulkowski, Ireneusz ; Tsa, Tsung-Han ; Jayaraman, Vijaysekhar ; Kraus, Martin ; Connolly, James L. ; Hornegger, Joachim ; Cable, Alex ; Fujimoto, James G.: Swept source optical coherence microscopy using a 1310 nm VCSEL light source. In: Optics Express 21 (2013), No. 15, pp 18021-18033
[doi>10.1364/OE.21.018021]
Tsai, Tsung-Han ; Tao, Yuankai K. ; Potsaid, Benjamin M. ; Jayaraman, Vijaysekhar ; Kraus, Martin ; Heim, Peter J. S. ; Hornegger, Joachim ; Mashimo, Hiroshi ; Cable, Alex E. ; Fujimoto, James G.: Ultrahigh speed endoscopic optical coherence tomography using micro-motor imaging catheter and VCSEL technology. In: SPIE (Ed.) : Proc. SPIE 8571 (Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII San Francisco, California, USA 02.02.2013). 2013, pp 85710N.
[doi>10.1117/12.2006952]

Institution: Chair of Computer Science 5 (Pattern Recognition)
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