Research project

Fusion of 3-D volumetric data sets and 2-D fluoroscopic sequences for application in electro-physiology ablation procedures

The goal of our research is to develop a method to fuse three-dimensional volumetric data sets (CACT, CT, MRI) to two-dimensional fluoroscopic sequences as they are acquired during electro-physiology procedures. The targeted application of this method is atrial fibrillation which is treated by electrically isolation of the pulmonary veins attached to the left atrium. Atrial fibrillation is the most common sustained heart arrhythmia. In the USA, about six million people suffer from this disease. Atrial fibrillation usually goes with a higher risk for strokes and cardiac insufficiency, and is often associated with a higher cardio-vascular morbidity in general. The required user interaction to fuse a three-dimensional volumetric data set to two-dimensional fluoroscopic sequences needs to be integrated into the physician's workflow.

Our research focuses on:

Motion compensation during the ablation
Registration of a three-dimensional volumetric data set to

two-dimensional fluoroscopic sequences.

Project manager:
Prof. Dr.-Ing. Joachim Hornegger

Project participants:
Dr.-Ing. Alexander Brost, Dr.-Ing. Norbert Strobel

Keywords:
Motion Compensation, Electro-Physiology, Registration

Duration: 1.5.2009 - 30.4.2011

Sponsored by:
Siemens AG, Healthcare Sector

Contact:
Brost, Alexander
E-Mail: alexander.brost@cs.fau.de

Publications

Brost, Alexander ; Liao, Rui ; Hornegger, Joachim ; Strobel, Norbert: 3-D Respiratory Motion Compensation during EP Procedures by Image-Based 3-D Lasso Catheter Model Generation and Tracking. In: Yang, G.-Z. ; Hawkes, D. J. ; Rueckert, D. ; Noble, J. A. ; Taylor, C. J. (Ed.) : Lecture Notes in Computer Science (MICCAI London, UK 20.-24.09.2009). Vol. 5761. London : Springer, 2009, pp 394–401.

Brost, Alexander ; Strobel, Norbert ; Yatziv, Liron ; Gilson, Wesley ; Meyer, Bernhard ; Hornegger, Joachim ; Lewin, Jonathan ; Wacker, Frank: Accuracy of x-ray image-based 3D localization from two C-arm views: a comparison between an ideal system and a real device. In: Miga, M. I. ; Wong, K. H. (Ed.) : Medical Imaging 2009, Visualization, Image-Guided Procedures, and Modeling (SPIE Orlando, FL, USA 07.-12.02.2009). 2009, pp 72611Z.

Brost, Alexander ; Liao, Rui ; Hornegger, Joachim ; Strobel, Norbert: 3D model-based catheter tracking for motion compensation in EP procedures. In: Kenneth H. Wong ; Michael I. Miga (Ed.) : Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling (SPIE Medical Imaging 2010 San Diego, CA, USA 13 - 18 February 2010). 2010, pp 762507.

Brost, Alexander ; Wimmer, Andreas ; Liao, Rui ; Hornegger, Joachim ; Strobel, Norbert: Catheter Tracking: Filter-Based vs. Learning-Based. In: Goesele, Michael ; Roth, Stefan ; Kuijper, Arjan ; Schiele, Bernt (Ed.) : Lecture Notes in Computer Science (DAGM 2010 Darmstadt, Germany 22 - 24 September 2010). Vol. 6376. Heidelberg, Berlin : Springer, 2010, pp 293-302.

Bourier, Felix ; Brost, Alexander ; Yatziv, Liron ; Hornegger, Joachim ; Strobel, Norbert ; Kurzidim, Klaus : Coronary Sinus Extraction for Multimodality Registration to guide Transseptal Puncture. In: Kahn, Thomas ; Jolesz, Ferenc A. ; Lewin, Jonathan S. (Ed.) : 8th Interventional MRI Symposium - Book of Abstracts (8th Interventional MRI Symposium Leipzig, Germany 24 - 25 September 2010). 2010, pp 311-313. - ISBN 978-3-00-032186-3

Brost, Alexander ; Liao, Rui ; Hornegger, Joachim ; Strobel, Norbert: Model-Based Registration for Motion Compensation during EP Ablation Procedures. In: Fischer, Bernd ; Dawant, Benoit ; Lorenz, Cristian (Ed.) : Lecture Notes in Computer Science (WBIR 2010 Luebeck, Germany 11 - 13 July 2010). Vol. 6204. Heidelberg, Berlin : Springer, 2010, pp 234-245.

Brost, Alexander ; Liao, Rui ; Strobel, Norbert ; Hornegger, Joachim: Respiratory motion compensation by model-based catheter tracking during EP procedures. In: Medical Image Analysis 14 (2010), No. 5, pp 695-706

Brost, Alexander ; Bourier, Felix ; Yatziv, Liron ; Koch, Martin ; Hornegger, Joachim ; Strobel, Norbert ; Kurzidim, Klaus: First Steps towards Initial Registration for Electrophysiology Procedures. In: SPIE (Ed.) : Proc. SPIE 7964 (Medical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling Lake Buena Vista, Florida, USA February). 2011, pp 79641P.

Brost, Alexander ; Wimmer, Andreas ; Liao, Rui ; Hornegger, Joachim ; Strobel, Norbert: Motion Compensation by Registration-Based Catheter Tracking. In: SPIE (Ed.) : Proc. SPIE 7964 (Medical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling Lake Buena Vista, Florida, USA 12.02 - 17.02.2011). Vol. 7964. 2011, pp 79641O.