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Respiratory Motion Estimation for SPECT ImagingIn the field of molecular imaging, biological processes
are observed at the cellular and molecular level. With
the help of radioactive tracers, physiological
developments can be localized and visualized in vivo. In
the case of single photon emission-computed tomography
(SPECT), a very small amount of radiopharmaceutical is
injected in order to minimize dose to the patient. To
obtain a sufficient number of photons for acceptable
image quality, SPECT acquisition times are typically in
excess of ten minutes. Due to these long time frames,
image quality is often impacted by patient motion. In
many cases, the unavoidable presence of respiratory
motion is a major source of artifacts and quantitative
inaccuracies. In this project, we aim to develop algorithms which will
characterize and estimate respiratory motion. With the
help of various procedures from the fields of pattern
recognition and image processing, motion fields
corresponding to acquisitions shall be generated. This
information will be subsequently forwarded to a modified
reconstruction algorithm to yield motion-corrected
images. | Project manager:
Prof. Dr.-Ing. Joachim Hornegger, Prof. Dr. med. Torsten Kuwert, A. Hans Vija, PhD
Project participants:
James Sanders, M. Sc.
Keywords:
Molecular Imaging; Emission Tomography; Iterative Reconstruction; Single Photon Emission-Computed Tomography; Nuclear Medicine; Respiratory Motion; Motion Correction; SPECT
Duration: 1.10.2013 - 30.9.2016
Sponsored by:
Siemens AG, Healthcare Sector
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Welz, F. ; Sanders, James ; Kuwert, T. ; Maler, J. ; Kornhuber, J. ; Ritt, P.: Absolute SPECT/CT quantification of cerebral uptake of 99mTc-HMPAO for patients with neurocognitive disorders. In: Nuklearmedizin 55 (2016), No. 1
[doi>10.3413/Nukmed-0765-15-09] | | Oppelt, Maximilian ; Sanders, James ; Maier, Andreas: Investigation of Single Photon Emission Computed Tomography Acquired on Helical Trajectories. In: Heinz Handels, Thomas M. Deserno, Hans-Peter Meinzer, Thomas Tolxdorff (Ed.) : Bildverarbeitung für die Medizin (BVM 2015 Lübeck 15.3-17.3). 2015, pp 504-509. | Sanders, James ; Kuwert, Torsten ; Hornegger, Joachim ; Ritt, Philipp: Quantitative SPECT/CT Imaging of (177)Lu with In Vivo Validation in Patients Undergoing Peptide Receptor Radionuclide Therapy. In: Molecular Imaging and Biology 17 (2015), No. 4, pp 585-593
[doi>10.1007/s11307-014-0806-4] | Ritt, Philipp ; Sanders, James ; Kuwert, Torsten: SPECT/CT Technology. Vol. 2 Clinical and Translational Imaging : Springer, 2014. - 445-457 pages.
[doi>10.1007/s40336-014-0086-7] |
Institution: Chair of Computer Science 5 (Pattern Recognition)
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