Structural Biology 1: Protein design and Designer proteins (StrBio1)7.5 ECTS
(englische Bezeichnung: Strukturbiologie 1: Proteindesign und Designerproteine)
(Prüfungsordnungsmodul: Structural BioIogy I: Protein Design and Designer Proteins)

Lectures:

• • Mastermodul Strukturbiologie I: Proteindesign und Designerproteine
    (Übung, 16 SWS, Yves Muller et al., single appointment on 5.3.2018, 9:15 - 10:00, Hörsaal ZMPT; single appointment on 6.3.2018, single appointment on 7.3.2018, 9:15 - 10:45, 00.581; single appointment on 8.3.2018, single appointment on 9.3.2018, 9:15 - 10:45, Hörsaal ZMPT; single appointment on 12.3.2018, 9:15 - 10:15, Hörsaal ZMPT; single appointment on 14.3.2018, 9:15 - 10:45, Hörsaal ZMPT; single appointment on 19.3.2018, 9:15 - 10:15, Hörsaal ZMPT; single appointment on 26.3.2018, 9:15 - 11:00, Hörsaal ZMPT; single appointment on 29.3.2018, 10:15 - 11:45, SR Biologie; from 5.3.2018 to 29.3.2018; Weitere Details zum Programm werden während der Veranstaltung bekannt gegeben.)

Empfohlene Voraussetzungen:

none

Inhalt:

Seminar talks cover theoretical and methodological approaches for the design of proteins with modified characteristics, including phage and ribosome display, directed evolution and computational protein design; Discussion of seminal protein design studies.

Laboratory course are focused on computational protein design (usingwe protein side-chain packing algorithms, or molecular dynamics simulation). Additionally, students are introduced into experimemtal validation techniques such as e.g. protein crystallography or CD spectroscopy in hands-on lab trainings.

The main part of the practical course is devoted to active cooperation in ongoing research projects of the participating labs.

Lernziele und Kompetenzen:

The students are

• acquainted with novel insights, concepts, and methods for the design of proteins with new, different characteristics

• understand state-of-the-art methods in protein design and their limitations

• are able to independently develop working hypotheses, to independently design and conduct experiments

• able to present and critically discuss current research articles / their results and defend their conclusions in proper context
  

Literatur:

introductory articles will be provided electronically

Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan:

1. Zell- und Molekularbiologie (Master of Science)
   (Po-Vers. 2015w | NatFak | Zell- und Molekularbiologie (Master of Science) | Mastermodule | Biologische Mastermodule | Structural BioIogy I: Protein Design and Designer Proteins)

Studien-/Prüfungsleistungen:

Portfolio exam Structural Biology I: Protein Design and Designer Proteins (Prüfungsnummer: 22011)

Prüfungsleistung, mehrteilige Prüfung, benotet

Anteil an der Berechnung der Modulnote: 100.0 %

weitere Erläuterungen:
Portfolio PL: mündliche Prüfung PL: mündliches Referat PL. schriftliches Protokoll

Erstablegung: WS 2017/2018

1. Prüfer:

Böckmann/Muller