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SFB 539, A4: Automated Glaucoma ScreeningThe Pattern Recognition Lab deals with automatic approaches for early
detection of glaucoma disease within the framework of SFB 539
(Collaborative Research Centre
539,http://www.sfb539.forschung.uni-erlangen.de ) subproject A4. The glaucoma disease causes a successive dying of the retinal nerve
fibers and thus is one major reason for blindness. The resulting
morphological changes of the optic nerve head (ONH), called glaucomatous
opticus atrophy, are one major indicator for the disease.
Current state of the art methods describe the morphology of the ONH
using geometric parameters such as normalized distances to gain well
discriminating features. In the current project period a novel Glaucoma Risk Index (GRI) was
developed that is based on data driven approaches to gain relevant
features well describing the appearance of th ONH. Thus, the approach no
longer exclusively relies on exact measurements of the ONH and other
prominent regions. Preprocessing eliminates non glaucomatous mutation
such as variation ofthe vessel tree, ONH size and illumination in order
to allow a pure image based classification approach. To capture
different characteristics the ONH images are compressed by principal
component analysis and interpreted as features in a 2-stage glaucoma
classification. This monomodal setup on the color fundus images achieves
an area under ROC of 0.85 that is competitive with established, but more
expensive methods. Due to the utilization of the inexpensive fundus
imaging the developed GRI provides first hints to early detect the
glaucoma disease. A intuitive and location independent access to the
calculation of the GRI is provided to the clinical personal by an web
interface. A further combination of the fundus image based GRI with further indices
of the Heidelberg Retina Tomograph (HRT) and functional FDT led to
futher increased AUC of 0.92. | Project manager: Prof. Dr.-Ing. Joachim Hornegger, Prof. Dr. med. Georg Michelson, Prof. Dr.rer.nat. Berthold Lausen
Project participants: Dipl.-Inf. Jörg Meier, Dipl.-Inf. Rüdiger Bock, PD Dr. rer. biol. hum. Dr. habil. med. Werner Adler, Attila Budai, M. Sc.
Keywords: glaucoma; appearance-based approach; segmentation; Hough-transform; active contours; optic nerve head;
Duration: 1.7.2003 - 31.12.2009
Sponsored by: Deutsche Forschungsgemeinschaft
Contact: Bock, Rüdiger E-Mail: ruediger.bock@cs.fau.de
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Bock, Rüdiger ; Meier, Jörg ; Nyúl, László G. ; Wärntges, Simone ; Michelson, Georg ; Hornegger, Joachim: Appearance-based Approach to Extract an Age-related Biomarkers from Retinal Images. In: Hornegger, Joachim ; Mayr, Ernst W. ; Schookin, Sergey ; Feußner, Hubertus ; Navab, Nassir ; Gulyaev, Yuri V. ; Höller, Kurt ; Ganzha, Victor (Ed.) : 3rd Russian-Bavarian Conference on Biomedical Engineering (3rd Russian-Bavarian Conference on Biomedical Engineering Erlangen 2.-3.07.2007). Vol. 1. Erlangen : Union aktuell, 2007, pp 127-131. | Meier, Jörg ; Bock, Rüdiger ; Michelson, Georg ; Nyúl, László G. ; Hornegger, Joachim: Effects of Preprocessing Eye Fundus Images on Appearance Based Glaucoma Classification. In: Kropatsch, Walter G. ; Kampel, Martin ; Hanbury, Allan (Ed.) : 12th International Conference on Computer Analysis of Images and Patterns, CAIP. Lecture Notes in Computer Science (LNCS) 4673 (12th International Conference on Computer Analysis of Images and Patterns (CAIP) Vienna 27-29 Aug. 2007). Vol. 4673/2007. Berlin : Springer, 2007, pp 165-173. - ISBN 978-3-540-74271-5 | Meier, Jörg ; Bock, Rüdiger ; Nyúl, László G. ; Michelson, Georg: Eye Fundus Image Processing System for Automated Glaucoma Classification. In: Scharff, Peter (Ed.) : 52. Internationales Wissenschaftliches Kolloquium: Computer Science meets automation (Internationales Wissenschaftliches Kolloquium: Computer Science meets automation Ilmenau 10-13 September). Vol. 2. Ilmenau : TU Ilmenau Universitätsbibliothek, 2007, pp 81-85. - ISBN 978-3-939473-17-6 | Bock, Rüdiger ; Meier, Jörg ; Michelson, Georg ; Nyúl, László G. ; Hornegger, Joachim: Classifying Glaucoma with Image-Based Features from Fundus Photographs. In: Hamprecht, Fred A. ; Schnörr, Christoph ; Jähne, Bernd (Ed.) : 9th Annual Symposium of the German Association for Pattern Recognition, DAGM. Lecture Notes in Computer Science (LNCS) 4713 (DAGM Heidelberg 12-14 Sept. 2007). Vol. 4713/2007. Berlin : Springer, 2007, pp 355-365. - ISBN 978-3-540-74933-2 | Bock, Rüdiger ; Meier, Jörg ; Nyúl, László G. ; Michelson, Georg ; Hornegger, Joachim: Retina Image Analysis System for Glaucoma Detection. In: Ges. f. Biomed.Technik (Ed.) : Biomedizinische Technik, BMT 2007 (41. Jahrestagung der Deutschen Gesellschaft für Biomedizinische Technik Aachen 26-29 September). Vol. 52. Aachen : Walter de Gruyter, 2007, pp CD-ROM. | Meier, Jörg ; Bock, Rüdiger ; Nyúl, László G. ; Hornegger, Joachim ; Michelson, Georg: Novel Visualization Approach of an Automated Image Based Glaucoma Risk Index for Intuitive Diagnosis. In: Jan, J. ; Konzuplik, J. ; Provaznik, I. (Ed.) : Analysis of Biomedical Signals and Images, Proceedings of the Biosignal 2008 International Eurasip Conference (Biosignal Brno, Czech Republic 29.6.2008-01.07.2008). Vol. 19, 1. Edition Brno, Czech Republic : Vutium Press, 2008, pp no pagination. - ISBN 978-80-214-3613-8 | Arold, Oliver J. ; Bock, Rüdiger ; Meier, Jörg ; Michelson, Georg ; Hornegger, Joachim: Optimierte Segmentierung der Papille in HRT-Retinaaufnahmen. In: GMDS, BVMI, IEEE (Org.) : Bildverarbeitung für die Medizin 2008 - Algorithmen, Systeme, Anwendungen (Bildverarbeitung für die Medizin 2008 Berlin 06. - 08. 04. 2008). 2008, pp 217-221. | Bock, Rüdiger ; Meier, Jörg ; Nyúl, László G. ; Hornegger, Joachim ; Michelson, Georg: Glaucoma Risk Index: Automated glaucoma detection from color fundus images. In: Medical Image Analysis 14 (2010), No. 3, pp 471-481 [doi>10.1016/j.media.2009.12.006] | Michelson, Georg ; Hornegger, Joachim ; Wärntges, Simone ; Lausen, Berthold: Die Papille als Screening-Parameter für die Früherkennung des Glaukoms – The papilla as screening parameter for early diagnosis of glaucoma. In: Deutsches Ärzteblatt (2008), No. 105, pp 585-589 | Michelson, Georg ; Hornegger, Joachim ; Lausen, Berthold: Die Papille als Screening-Parameter auf Glaukom - Die Papille beim Glaukom. In: Krieglstein, G.K. (Ed.) : Glaukom 2007. Heidelberg : Springer, 2008, pp 137-148. |
Institution: Chair of Computer Science 5 (Pattern Recognition)
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