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| Role of Vinculin in Carcinoma Cells Among the most common and devastating forms of tumors is breast cancer. Vinculin is known to be a component of the adhesion complex of cytoskeletal proteins in tissue. The disruption and restoration of the interactions of this protein in F9 and MEF carcinoma cells present an ideal opportunity to study the underlying mechanisms of actin-membrane attachments. In the proposed study, we will examine F9 and MEF carcinoma cells deficient of vinculin, produced genetically by homologous recombination, and vinculin-transfected F9 cell lines to clarify both the function of vinculin in cytoskeletal organization and the effect of vinculin on the mechanical and regulatory properties of the cell. | Project manager:
Prof. Wolfgang Goldmann, Ph.D., Prof. Dr. H. Vali
Project participants:
Dipl.-Biochem. Gerold Diez
Duration: 1.1.2007 - 31.12.2007
Sponsored by:
Kooperationsprogramm Bayern-Québec (BFHZ)
Mitwirkende Institutionen:
McGill University, Dept. of Anatomy and Cell Biology, Montreal, Kanada
Contact:
Goldmann, Wolfgang
Phone +49 (0) 9131 85-25605, Fax +49 (0) 9131 85-25601, E-Mail: wgoldmann@biomed.uni-erlangen.de
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Diez, Gerold ; List, F ; Smith, J ; Ziegler, WH ; Goldmann, Wolfgang: Direct evidence of vinculin tail - lipid membrane interaction in beta-sheet conformation.. In: Biochem Biophys Res Commun 373 (2008), pp 69-73
[doi>10.1016/j.bbrc.2008.05.182] | Mierke, Claudia ; Kollmannsberger, Philip ; Paranhos Zitterbart, D ; Smith, J ; Fabry, Ben ; Goldmann, Wolfgang: Mechano-coupling and regulation of contractility by the vinculin tail domain.. In: Biophysical Journal 94 (2008), pp 661-670
[doi>10.1529/biophysj.107.108472] |
Institution: Lehrstuhl für Biophysik (Prof. Dr. Fabry)
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