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Structural Biology 1: Protein design and Designer proteins (StrBio1)7.5 ECTS (englische Bezeichnung: Strukturbiologie 1: Proteindesign und Designerproteine)
Modulverantwortliche/r: Yves Muller Lehrende:
Rainer Böckmann, Yves Muller, Benedikt Schmid
Start semester: |
WS 2015/2016 | Duration: |
1 semester | Cycle: |
jährlich (WS) |
Präsenzzeit: |
120 Std. | Eigenstudium: |
105 Std. | Language: |
Deutsch |
Lectures:
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Mastermodul Strukturbiologie I: Proteindesign und Designerproteine
(Übung, 16 SWS, Yves Muller et al., single appointment on 7.3.2016, 9:15 - 10:00, Hörsaal ZMPT; single appointment on 8.3.2016, single appointment on 9.3.2016, 9:15 - 10:45, Hörsaal ZMPT; single appointment on 11.3.2016, single appointment on 14.3.2016, 9:15 - 10:45, SR Biologie; single appointment on 15.3.2016, 9:15 - 10:00, Hörsaal ZMPT; single appointment on 16.3.2016, 9:15 - 10:45, SR Biologie; single appointment on 17.3.2016, 9:15 - 10:15, Hörsaal ZMPT; single appointment on 29.3.2016, 9:15 - 14:00, Hörsaal ZMPT; single appointment on 1.4.2016, 10:15 - 11:45, SR Biologie; from 7.3.2016 to 1.4.2016; 10 Plätze; Anmeldung (auch für Mastermodul Biotechnik II für das SS 2016!): Details und Anmeldetermin werden noch bekannt gebeben.)
Empfohlene Voraussetzungen:
none
Inhalt:
Seminar talks cover theoretical and methodological approaches for the design of proteins with modified characteristics, including phage and ribosome display, directed evolution and computational protein design; Discussion of seminal protein design studies. Laboratory course are focused on computational protein design (usingwe protein side-chain packing algorithms, or molecular dynamics simulation). Additionally, students are introduced into experimemtal validation techniques such as e.g. protein crystallography or CD spectroscopy in hands-on lab trainings. The main part of the practical course is devoted to active cooperation in ongoing research projects of the participating labs.
Lernziele und Kompetenzen:
The students are
acquainted with novel insights, concepts, and methods for the design of proteins with new, different characteristics
understand state-of-the-art methods in protein design and their limitations
are able to independently develop working hypotheses, to independently design and conduct experiments
able to present and critically discuss current research articles / their results and defend their conclusions in proper context
Literatur:
introductory articles will be provided electronically
Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan: Das Modul ist im Kontext der folgenden Studienfächer/Vertiefungsrichtungen verwendbar:
- 643#65#H
(Po-Vers. 2012 | Modulgruppen | MG1: Mathematische Modellierung und Systembiologie | Wahlpflichtmodule der Modulgruppe1 | Structural BioIogy I: Protein Design and Designer Proteins)
- 643#65#H
(Po-Vers. 2012 | Modulgruppen | MG2: Bioimaging und Biophysik | Wahlpflichtmodule der Modulgruppe2 | Structural BioIogy I: Protein Design and Designer Proteins)
- 643#65#H
(Po-Vers. 2012 | Modulgruppen | MG3: Biologische Strukturen und Prozesse | Wahlpflichtmodule der Modulgruppe3 | Structural BioIogy I: Protein Design and Designer Proteins)
- Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science)
(Po-Vers. 2015w | Module Groups | MG3: Biological Structures and Processes | Mandatory Elective Modules Group 3 | Structural BioIogy I: Protein Design and Designer Proteins)
- Zell- und Molekularbiologie (Master of Science)
(Po-Vers. 2008 | Mastermodule | Biologische Mastermodule | Structural BioIogy I: Protein Design and Designer Proteins)
- Zell- und Molekularbiologie (Master of Science)
(Po-Vers. 2015w | Mastermodule | Biologische Mastermodule | Structural BioIogy I: Protein Design and Designer Proteins)
Studien-/Prüfungsleistungen:
Portfolio exam Structural Biology I: Protein Design and Designer Proteins (Prüfungsnummer: 22011)
- Prüfungsleistung, mehrteilige Prüfung, benotet
- Anteil an der Berechnung der Modulnote: 100.0 %
- weitere Erläuterungen:
Portfolio
PL: mündliche Prüfung
PL: mündliches Referat
PL. schriftliches Protokoll
- Erstablegung: WS 2015/2016
1. Prüfer: | Böckmann/Muller |
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