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Drug discovery (MSM-life)30 ECTS (englische Bezeichnung: Drug discovery)
Modulverantwortliche/r: Peter Gmeiner Lehrende:
Andreas Burkovski, Jutta Eichler, Peter Gmeiner, Markus Heinrich, Harald Lanig, Jürgen Schatz, u.a.
Start semester: |
SS 2018 | Duration: |
2 semester | Cycle: |
halbjährlich (WS+SS) |
Präsenzzeit: |
450 Std. | Eigenstudium: |
450 Std. | Language: |
Englisch |
Lectures:
Mandatory courses:
Seminars:
Drug Discovery-Seminar (7SEM)
Drug Discovery-Laboratory course (23LAB):
10 week block lab project in one of the participating research groups (Profs. Burkovski, Burzlaff, Eichler, Gmeiner, Heinrich, Ivanovic-Burmazovic, Koch, Lanig, Muller, Nitschke, Schatz, Stadler, Winkler, Zahn)
with
Seminar Research projects (1S): oral presentation (20
min, plus discussion)
Seminar Journal club (group seminar in one of the re-
search groups)(2S)
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Drug Discovery Praktikum (SS 2018)
(Praktikum, 23 SWS, Peter Gmeiner et al., Zeit und Raum n.V.)
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Drug Discovery Seminar (SS 2018)
(Seminar, 7 SWS, Andreas Burkovski et al., Mon, 14:00 - 16:00, C4 - Chemikum; Tue, 14:30 - 17:00, C4 - Chemikum; Wed, 17:00 - 19:00, C4 - Chemikum; single appointment on 16.7.2018, single appointment on 17.7.2018, 8:00 - 18:00, C4 - Chemikum; starting 10.4.2018; ; Presentation of Projects: Monday, 16. July 2018 and Tuesday, 17. July 2018; Seminar start in summerterm 2018: Tuesday, 10.4.2018)
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Drug Discovery Praktikum (WS 2018/2019)
(Praktikum, 23 SWS, Peter Gmeiner et al., Zeit und Raum n.V.)
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Drug Discovery Seminar (WS 2018/2019)
(Seminar, 7 SWS, Andreas Burkovski et al., Mon, 14:15 - 16:00, C4 - Chemikum; Tue, 14:15 - 17:00, C4 - Chemikum; Wed, 17:00 - 19:00, C4 - Chemikum; Start/Beginn (Introduction/Einführungsveranstaltung): Tuesday, 16th october 2018, 14:15 , C4, Please join on StudOn: Drug Discovery (MSM-life) WS 2018/19 and SS 2019, Lecture on wednesdays only after special announcement)
Empfohlene Voraussetzungen:
Admission to the M. Sc. program Molecular Science or Chemistry
Inhalt:
Drug Discovery-SEMINAR
Genomics, transcriptomics, proteomics; in-vitro assay systems, assay technology; target screening and drug production in plants, drug screening and production in yeast; experimental structural biology; chemoinformatics; molecular modeling: molecular dynamics simulation, force-fields, modeling of proteins, proteinligand docking; drug synthesis and combinatorial chemistry; redox-active metal complexes,
metalloenzyme inhibitors; stereochemistry in drug design; organic reactions in medicinal chemistry; drug metabolism; peptidomimetics;
LAB Course
Project course: Lab projects focusing on the modern research issues in one of the participating research groups.
Seminar research projects:
students reports on lab projects.
Discussions on recent publications in the field of drug discovery (within the respective research units).
Lernziele und Kompetenzen:
The students are able
to understand the basic and advanced principles of medicinal chemical, molecular biological and computer
chemistry based applications in the field of modern drug design research
to utilize modern experimental techniques to prepare and characterize various samples with in the lab project
to apply modern simulation techniques for the modeling of proteins
to interpret and to critically summarize experimental results in written form (lab report), and to present and discuss these results within the research group or in front of a student audience
to participate in planning, developing and executing of experimental routes for the synthesis of drugs
to judge and to discuss in oral form their research results in the field of drug discovery in comparison to recent publications.
Literatur:
Manuscripts are available on StudON,
additional reading, e.g. G. Klebe, Drug Design: Methodology, Concepts, and Mode-of-Action, Springer 2013
Bemerkung:
Courses of study for which the module is acceptable:
M.Sc. Molecular Lifescience
Organisatorisches:
Intended stage in the degree course: Mandatory module
for M.Sc. Molecular Lifescience
semester 1 and 2
Frequency of offer: Annually / start of studies is strongly recommended in winter term
Workload: 900 hours (includes 450 hours private studies
and 50 contact hours)
Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan: Das Modul ist im Kontext der folgenden Studienfächer/Vertiefungsrichtungen verwendbar:
- Molecular Science (Master of Science)
(Po-Vers. 2007 | NatFak | Molecular Science (Master of Science) | alte Prüfungsordnungen | Masterprüfung | Pflichtmodul Molecular Science)
- Molecular Science (Master of Science)
(Po-Vers. 2013 | NatFak | Molecular Science (Master of Science) | Pflichtmodul Molecular Science)
Studien-/Prüfungsleistungen:
Drug Discovery (Prüfungsnummer: 30702)
(englischer Titel: Drug Discovery)
- Prüfungsleistung, mündliche Prüfung, Dauer (in Minuten): 45, benotet
- Anteil an der Berechnung der Modulnote: 100.0 %
- weitere Erläuterungen:
Assessment and examinations Portfolio:
PL Oral examination (O 45min, 3 examiners)
LEC (PL)
LAB (PL, AP)
Lab course protocol (without explicite mark) + oral presentation of research project (20 min + discussion); Calculation of the grade for the module: PL:
O45 (66 %)
LEC (PL) (17 %)
LAB (PL, AP) (17 %)
- Prüfungssprache: Englisch
- Erstablegung: WS 2018/2019, 1. Wdh.: SS 2019
1. Prüfer: | Markus Heinrich |
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