Tissue Perfusion Quantification with C-arm CTQuantification of the cerebral blood flow (perfusion) inside
the brain is a
well-established procedure for stroke diagnosis that is
currently performed
using computed tomography (CT) or magnetic resonance imaging
(MRI). In this
project the use of a C-arm angiographic system (C-arm CT) is
investigated to
quantify perfusion. With this imaging modality tomographic images can be
acquired shortly ahead,
during and after the intervention when the patient is
positioned on the
treatment table. There are huge potential benefits with this
technique when
diagnosing stroke: Less resources are blocked because no CT
or MRI scanner is
needed and, most of all, the time interval between the scan
and the start of the
therapy can be reduced significantly. The aim of this project is to develop novel dynamic
reconstruction algorithms
for perfusion imaging that can be used with slowly rotating
scanners like C-arm
CT scanners. Also iterative, Compressed Sensing based
algorithms are studied,
particularly to reduce the X-ray dose to the patient.
| Project manager:
Prof. Dr.-Ing. Joachim Hornegger
Project participants:
Dr.-Ing. Michael Manhart, André Aichert, M. Sc.
Keywords:
Medical Image Processing; Perfusion; C-arm CT
Duration: 15.2.2008 - 30.4.2015
Sponsored by:
Siemens AG, Healthcare Sector
Mitwirkende Institutionen:
Stanford University, Department of Radiology
Neuroradiologische Abteilung im Radiologischen Institut
Contact:
Manhart, Michael
E-Mail: michael.manhart@cs.fau.de
| | Publications |
|---|
| Fieselmann, Andreas ; Ganguly, Arundhuti ; Deuerling-Zheng, Yu ; Zellerhoff, Michael ; Boese, Jan ; Hornegger, Joachim ; Fahrig, Rebecca: A Dynamic Reconstruction Approach for Cerebral Blood Flow Quantification With an Interventional C-arm CT. In: IEEE (Ed.) : Proceedings ISBI 2010 (2010 IEEE International Symposium on Biomedical Imaging (ISBI): From Nano to Macro Rotterdam, The Netherlands 14.-17.04.2010). 2010, pp 53-56. | | Ganguly, Arundhuti ; Fieselmann, Andreas ; Boese, Jan ; Rohkohl, Christopher ; Hornegger, Joachim ; Fahrig, Rebecca : Evaluating the Feasibility of C-arm CT for Brain Perfusion Imaging: An in vitro Study. In: Wong, Kenneth, H. ; Miga, Michael I. (Ed.) : Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling (SPIE Medical Imaging 2010 San Diego, CA, USA 12.-17.02.2010). 2010, pp 76250K. | | Fieselmann, Andreas ; Ganguly, Arundhuti ; Deuerling-Zheng, Yu ; Boese, Jan ; Fahrig, Rebecca ; Hornegger, Joachim: Using a C-arm CT for Interventional Perfusion Imaging: A Phantom Study to Measure Linearity Between Iodine Concentration and Hounsfield Values. In: DGMP (Ed.) : Medizinische Physik 2010 (41. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik Freiburg i.Br., Germany 29.09.2010-02.10.2010). 2010, pp n/a. | | Fieselmann, Andreas ; Ganguly, Arundhuti ; Deuerling-Zheng, Yu ; Zellerhoff, Michael ; Marks, Michael ; Boese, Jan ; Fahrig, Rebecca: Volume Cerebral Blood Flow (CBF) Measurement Using an Interventional Ceiling-Mounted C-arm Angiography System. In: ESR (Ed.) : Insights Into Imaging (European Congress of Radiology (ECR) 2010 Vienna, Austria 04-08.03.2010). Berlin/Heidelberg : Springer, 2010, pp 186. | Fieselmann, Andreas ; Dennerlein, Frank ; Deuerling-Zheng, Yu ; Boese, Jan ; Fahrig, Rebecca ; Hornegger, Joachim: A model for filtered backprojection reconstruction artifacts due to time-varying attenuation values in perfusion C-arm CT. In: Physics in Medicine and Biology 56 (2011), No. 12, pp 3701-3717
[doi>10.1088/0031-9155/56/12/016] | Fieselmann, Andreas ; Ganguly, Arundhuti ; Deuerling-Zheng, Yu ; Boese, Jan ; Hornegger, Joachim ; Fahrig, Rebecca: Automatic measurement of contrast bolus distribution in carotid arteries using a C-arm angiography system to support interventional perfusion imaging. In: SPIE (Org.) : Proc. SPIE 7964 (Medical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling Lake Buena Vista, FL, USA 13.02.2011). 2011, pp 79641W1-79641W6.
[doi>10.1117/12.877658] | Ganguly, Arundhuti ; Fieselmann, Andreas ; Marks, Michael ; Rosenberg, Jarrett ; Boese, Jan ; Deuerling-Zheng, Yu ; Straka, Matus ; Zaharchuk, Greg ; Bammer, Roland ; Fahrig, Rebecca: Cerebral CT Perfusion Using an Interventional C-Arm Imaging System: Cerebral Blood Flow Measurements. In: American Journal of Neuroradiology 32 (2011), No. 8, pp 1525-1531
[doi>10.3174/ajnr.A2518] | Fieselmann, Andreas ; Kowarschik, Markus ; Ganguly, Arundhuti ; Hornegger, Joachim ; Fahrig, Rebecca: Deconvolution-Based CT and MR Brain Perfusion Measurement: Theoretical Model Revisited and Practical Implementation Details. In: International Journal of Biomedical Imaging (2011), pp 20 pages
[doi>10.1155/2011/467563] | | Manhart, Michael: Dynamic Iterative Reconstruction for Interventional 4-D C-arm CT Perfusion Imaging (Talk).Talk: X-ray Seminars, Radiological Science Lab, Palo Alto, CA, USA, 06.11.2012 | | Manhart, Michael ; Fieselmann, Andreas ; Deuerling-Zheng, Yu: Evaluation of a Tight Frame Reconstruction Algorithm for Perfusion C-arm CT Using a Realistic Dynamic Brain Phantom. In: Noo, Frédéric (Ed.) : Proc. of the Second International Conference on Image Formation in X-Ray Computed Tomography (The Second International Conference on Image Formation in X-Ray Computed Tomography Salt Lake City, UT, USA 26.6.2012). 2012, pp 123-126. | | Manhart, Michael: Evaluation of a Tight Frame Reconstruction Algorithm for Perfusion C-arm CT Using a Realistic Dynamic Brain Phantom (Talk).Talk: The Second International Conference on Image Formation in X-Ray Computed Tomography, University of Utah, Salt Lake City, UT, USA, 26.06.2012 | | Manhart, Michael: Fast Dynamic Reconstruction Algorithm with Joint Bilateral Filtering for Perfusion C-arm CT (Poster).Talk: IEEE Nuclear Science Symposium, Medical Imaging Conference, IEEE, Anaheim, CA, USA, 01.11.2012 | | Royalty, Kevin ; Manhart, Michael ; Pulfer, Kari ; Deuerling-Zheng, Yu ; Strother, Charles ; Fieselmann, Andreas ; Consigny, Daniel: C-Arm CT Measurement of Cerebral Blood Volume and Cerebral Blood Flow Using a Novel High-Speed Acquisition and a Single Intravenous Contrast Injection. In: American Journal of Neuroradiology 34 (2013), No. 11, pp 2131-2138 | Fieselmann, Andreas ; Manhart, Michael: C-arm CT Perfusion Imaging in the Interventional Suite. In: Current Medical Imaging Reviews 9 (2013), No. 2, pp 96-101
[doi>10.2174/1573405611309020004] | Manhart, Michael ; Kowarschik, Markus ; Fieselmann, Andreas ; Deuerling-Zheng, Yu ; Royalty, Kevin ; Maier, Andreas ; Hornegger, Joachim: Dynamic Iterative Reconstruction for Interventional 4-D C-Arm CT Perfusion Imaging. In: IEEE Transactions on Medical Imaging 32 (2013), No. 7, pp 1336-1348
[doi>10.1109/TMI.2013.2257178] |
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