Research project

Advanced Multimodal Cardiac Modeling and OR Integration

In current clinical practice, minimally invasive procedures are starting to replace open heart surgeries. As there is no direct view or access to the affected anatomy, there is a high demand for predictive models, sophisticated planning and operating room (OR) integration tools. In the context of transcatheter therapies, such as the Transcatheter Aortic Valve Implantation (TAVI), biomarkers of the entire aortic-mitral apparatus must be extracted in order to perform patient selection and risk assessment as well as device selection and operation optimization. Current methods are able to extract basic biomarkers such as diameter, area measurements and C-arm angulations, but they fail to model the entire left-heart system and are neglecting the true volumetric physiology of the aortic root and leaflets. These features are mandatory for extracting advanced biomarkers as well as for computational modeling of biomechanics and fluid dynamics.

The main research focus lies on the development of novel segmentation algorithms for volumetric models of the subvalvular apparatus, in particular the aortic and mitral valve. Imaging modalities which offer high spatial resolution will be utilized to extract these volumetric models. Furthermore, we will explore the value of modalities with high temporal resolution for this purpose.

Project manager:
Prof. Dr.-Ing. habil. Andreas Maier, Dr. Michael Sühling

Project participants:
Dominik Neumann, M. Sc.

Keywords:
Medical Image Processing;Segmentation;Heart Valve;Cardiovascular Disease;Modeling;Biomechanical Models;Simulation

Duration: 1.1.2013 - 31.12.2015

Sponsored by:
Siemens AG, Corporate Technology, Erlangen

Contact:
Maier, Andreas
Phone +49 9131 85 27883, Fax +49 9131 85 27270, E-Mail: andreas.maier@fau.de

Publications

Neumann, Dominik ; Grbic, Sasa ; Mansi, Tommaso ; Voigt, Ingmar ; Rabbah, Jean-Pierre ; Siefert, Andrew ; Saikrishnan, Neelakantan ; Yoganathan, Ajit ; Yuh, David ; Ionasec, Razvan: Multi-modal Pipeline for Comprehensive Validation of Mitral Valve Geometry and Functional Computational Models. In: Young, Alistair (Ed.) : 4th International Workshop on Statistical Atalses and Computational Models of the Heart (MICCAI STACOM Workshop Nagoya, Japan 26.09.2013). Heidelberg : Springer, 2013, pp n/a.

Neumann, Dominik ; Mansi, Tommaso ; Grbic, Sasa ; Voigt, Ingmar ; Georgescu, Bogdan ; Kayvanpour, Elham ; Amr, Ali ; Sedaghat-Hamedani, Farbod ; Haas, Jan ; Katus, Hugo ; Meder, Benjamin ; ; Kamen, Ali ; Comaniciu, Dorin: Automatic Image-to-Model Framework for Patient-specific Electromechanical Modeling of the Heart. In: IEEE (Ed.) : 2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI) (2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI) Beijing, China 29.04.2014). 2014, pp 935-938. - ISBN 978-1-4673-1961-4

Zettinig, Oliver ; Mansi, Tommaso ; Neumann, Dominik ; Georgescu, Bogdan ; Rapaka, Saikiran ; Seegerer, Philipp ; Kayvanpour, Elham ; Sedaghat-Hamedani, Farbod ; Amr, Ali ; Haas, Jan ; Steen, Henning ; Katus, Hugo ; Meder, Benjamin ; Navab, Nassir ; Kamen, Ali ; Comaniciu, Dorin: Data-Driven Estimation of Cardiac Electrical Diffusivity from 12-Lead ECG Signals. In: Medical Image Analysis 18 (2014), No. 8, pp 1361-1376
[doi>10.1016/j.media.2014.04.011]

Seegerer, Philipp ; Mansi, Tommaso ; Jolly, Marie-Pierre ; Neumann, Dominik ; Georgescu, Bogdan ; Kamen, Ali ; Kayvanpour, Elham ; Amr, Ali ; Sedaghat-Hamedani, Farbod ; Haas, Jan ; Katus, Hugo ; Meder, Benjamin ; Comaniciu, Dorin: Estimation of Regional Electrical Properties of the Heart from 12-Lead ECG and Images. In: Camara, Oscar ; Mansi, Tommaso ; Pop, Mihaela ; Rhode, Kawal ; Sermesant, Maxime ; Young, Alistair (Ed.) : Proceedings of the 5th International STACOM Workshop (Statistical Atlases and Computational Modeling of the Heart (in conjunction with MICCAI) Cambridge, MA 18.09.2014). Berlin Heidelberg : Springer, 2014, pp 1-9. (LNCS Vol. 8896)

Grbic, Sasa ; Easley, Thomas F ; Mansi, Tommaso ; Bloodworth, Charles H ; Pierce, Eric L ; Voigt, Ingmar ; Neumann, Dominik ; Krebs, Julian ; Yuh, David D ; Jensen, Morten O ; Comaniciu, Dorin ; Yoganathan, Ajit P: Multi-modal Validation Framework of Mitral Valve Geometry and Functional Computational Models. In: Camara, Oscar ; Mansi, Tommaso ; Pop, Mihaela ; Rhode, Kawal ; Sermesant, Maxime ; Young, Alistair (Ed.) : Proceedings of the 5th International STACOM Workshop (Statistical Atlases and Computational Modeling of the Heart (in conjunction with MICCAI) Cambridge, MA 18.09.2014). Berlin Heidelberg : Springer, 2014, pp 239-248. (LNCS Vol. 8896)

Neumann, Dominik ; Mansi, Tommaso ; Georgescu, Bogdan ; Kamen, Ali ; Kayvanpour, Elham ; Amr, Ali ; Sedaghat-Hamedani, Farbod ; Haas, Jan ; Katus, Hugo ; Meder, Benjamin ; ; Comaniciu, Dorin: Robust Image-Based Estimation of Cardiac Tissue Parameters and Their Uncertainty from Noisy Data. In: Golland, Polina ; Hata, Nobuhiko ; Barillot, Christian ; ; Howe, Robert (Ed.) : Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2014 (International Conference on Medical Image Computing and Computer-Assisted Intervention Cambridge, MA 09.2014). Boston, USA : Springer, 2014, pp 9-16.