Sequence Analysis and Statistical Genomics (ILS-MA-B14)5 ECTS
(englische Bezeichnung: Sequenzanalyse und statistische Genomik)

Lehrveranstaltungen:

• • Sequence Analysis and Statistical Genomics
    (Vorlesung mit Übung, 4 SWS, Leila Taher, Di, 16:00 - 19:00, Praktikum 2 / 00.327-128; Einzeltermine am 31.5.2016, 12.7.2016, 16:00 - 19:00, SR Biologie)

Empfohlene Voraussetzungen:

none

Inhalt:

The course aims to present some of the most basic algorithms and statistical models for DNA sequence analysis. It focuses on teaching students how to formulate a problem as a mathematical and computational problem, and then solve it using efficient algorithms and appropriate statistical methods.

Lecture:
The lectures will cover basic data visualization and summarization, statistical methods, parameter estimation, hypothesis testing, sequence alignment and genome assembly algorithms, population variation, and genome association studies.

Computer Lab:
Students will work on problems and through statistical analyses using the freely available software R.

Lernziele und Kompetenzen:

The students

• appreciate the stochastic nature of biological phenomena

• summarize and visualize data

• understand some commonly used algorithms in genomics

• understand the mathematical models behind population association studies

• choose appropriate statistical methods to assess statistical significance

• critically evaluate and interpret statistical methods used in primary research articles

• implement a variety of analytical tasks on real datasets
  

Literatur:

Bioinformatics for Biologists (Cambridge University Press)
Biological Sequence Analysis (Cambridge University Press)
Algorithms on Strings, Trees, and Sequences (Cambridge University Press)

Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan:
Das Modul ist im Kontext der folgenden Studienfächer/Vertiefungsrichtungen verwendbar:

1. 643#65#H
   (Po-Vers. 2012 | NatFak | Integrated Life Sciences: Biologie, Biomathematik, Biophysik (Master of Science) | Modulgruppen | MG1: Mathematische Modellierung und Systembiologie | Wahlpflichtmodule der Modulgruppe1 | Sequence Analysis and Statistical Genomics)
2. Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science)
   (Po-Vers. 2015w | NatFak | Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science) | Module Groups | MG1: Mathematical Modelling and Systems Biologie | Mandatory Elective Modules Group 1 | Sequence Analysis and Statistical Genomics)
3. Zell- und Molekularbiologie (Master of Science)
   (Po-Vers. 2008 | NatFak | Zell- und Molekularbiologie (Master of Science) | Nichtbiologisches Wahlmodul | Sequence Analysis and Statistical Genomics)
4. Zell- und Molekularbiologie (Master of Science)
   (Po-Vers. 2015w | NatFak | Zell- und Molekularbiologie (Master of Science) | Nichtbiologisches Wahlmodul | Sequence Analysis and Statistical Genomics)

Studien-/Prüfungsleistungen:

Graded homework: Sequence Analysis and Statistical Genomics (Prüfungsnummer: 83801)

Prüfungsleistung, Hausarbeit, benotet, 5 ECTS

Anteil an der Berechnung der Modulnote: 100.0 %

Erstablegung: SS 2016

1. Prüfer:

Leila Taher

Termin: 08.08.2016
Termin: 01.08.2017, 15:30 Uhr